Long-term alpha interferon treatment is effective on anaemia and significantly reduces iron overload in congenital dyserythropoiesis type I
| Autor: | André Wagner, Serge Carillo, Laurent Henry, Jeanne Ramos, Isabelle Guiraud, Jean Paul Bureau, Pierre Blanc, Christophe Delfour, Thierry Lavabre-Bertrand |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test biology business.industry Anemia Alpha interferon Hematology General Medicine medicine.disease Gastroenterology Congenital dyserythropoietic anemia type I Ferritin Interferon Pegylated interferon Internal medicine Immunology Biopsy medicine biology.protein In patient business medicine.drug |
| Zdroj: | European Journal of Haematology. 73:380-383 |
| ISSN: | 0902-4441 |
| DOI: | 10.1111/j.1600-0609.2004.00310.x |
| Popis: | Interferon has been shown to be an effective treatment of congenital dyserythropoiesis type I (CDA-I), but the optimal dose and the feasibility of this treatment remains to be determined. Here, in a 9-yr follow-up of a single patient, we show that interferon remains active during such a long period. The optimal dose of conventional alpha interferon could be evaluated at 2 million units twice a week. Pegylated interferon could be used as well at a dose of 30 microg/wk. During interferon treatment, serum and erythrocyte ferritin levels decreased progressively, and remained inversely correlated with haemoglobin levels. On repeated liver biopsies, iron overload could be normalized. Low dose interferon is a long-term treatment of CDA-I, and allows a significant decrease in iron overload, that could be interesting even in patients who are only moderately anaemic. |
| Databáze: | OpenAIRE |
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