The Humanistic and Economic Burden of Chronic Idiopathic Constipation in the USA: A Systematic Literature Review
| Autor: | Renu M. Vekaria, Deirdre Mladsi, Molly Purser, Arpita Nag, Susan A Martin, Oyebimpe Olayinka-Amao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Pediatrics education.field_of_study business.industry Population Gastroenterology Alternative medicine medicine.disease 03 medical and health sciences Chronic idiopathic constipation 0302 clinical medicine Systematic review Functional gastrointestinal disorder Quality of life 030220 oncology & carcinogenesis medicine Absenteeism Functional constipation 030211 gastroenterology & hepatology education business |
| Zdroj: | Clinical and Experimental Gastroenterology. 13:255-265 |
| ISSN: | 1178-7023 |
| DOI: | 10.2147/ceg.s239205 |
| Popis: | Background Chronic idiopathic constipation (CIC) is a functional gastrointestinal disorder with an estimated prevalence of 16% in the USA; however, the humanistic and economic burden of CIC is poorly characterized. Aim This systematic literature review aimed to assess the humanistic and economic burden of CIC in adults in the USA. Methods Two systematic literature searches of English-language publications on the humanistic and economic burden of CIC in adults in the USA were conducted using electronic databases and other resources. Both searches included the terms "chronic idiopathic constipation" and "functional constipation". Specific terms used in the search on humanistic burden included "quality of life", "SF-36", "SF-12", and "PAC-QOL"; search terms for economic burden included "cost", "resource use", "absenteeism", and "productivity". Results Overall, 16 relevant articles were identified. Health-related quality of life (HRQoL) appeared to be reduced in patients with CIC compared with controls and the general US population. Abdominal (r=0.33-0.49), stool (r=0.23-0.33), and rectal symptoms (r=0.53) appeared to be associated with reduced HRQoL. Younger age and female sex were associated with reduced overall HRQoL and greater symptom severity. Direct outpatient costs were higher in patients with CIC than those without CIC (US$6284 vs US$5254). Patients with CIC and abdominal symptoms reported more days of disrupted productivity per month than those without abdominal symptoms (3.2 days vs 1.2 days). The overall prevalence of complementary and alternative medicine use by patients with CIC was similar to that in the general US population. Conclusion The reduced HRQoL and increased costs associated with CIC indicate unmet therapeutic need in this disorder. Further research is required to better understand the humanistic and economic burden of CIC in the USA. |
| Databáze: | OpenAIRE |
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