Amidines and related compounds. 6. Structure-activity relations of antihypertensive and antisecretory agents related to clonidine

Autor:	Timothy Jen, R. A. Mclean, Groves W, Bernard Loev, Van Hoeven H
Rok vydání:	1975
Předmět:	Chemistry Antisecretory agents Pharmacology Gastric secretion Pyrrolidine Clonidine Amidine chemistry.chemical_compound Oral administration Imidazolidine Drug Discovery medicine Molecular Medicine medicine.drug
Zdroj:	Journal of Medicinal Chemistry. 18:90-99
ISSN:	1520-4804 0022-2623
Popis:	Correlations of antihypertensive and antisecretory activities with various structural modifications of the antihypertensive agent clonidine (2-(2,6-dichlorophenylimino)imidazolidine) are described. Eleven chemical classes of compounds containing an "amidine" moiety were prepared in this study. The antihypertensive activity of these compounds was evaluated in metacorticoid hypertensive rats and unanesthetized neurogenic hypertensive dogs following oral administration. Antisecretory activity was evaluated in fistula rats by measuring pH and volume of gastric secretion. Two compounds, 2-(2,6-dimethylphenylimino)imidazolidine and 2-(2,6-dichlorophenylimino)pyrrolidine, are particularly effective antisecretory agents with minimal antihypertensive activity.
Databáze:	OpenAIRE
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