Biochemical targets of xenobiotics: Biomarkers in amphibian ecotoxicology
| Autor: | Ana M. Pechen de D'Angelo, Andrés Venturino |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
biology
Ecology Feminization (biology) Cytochrome P450 Carboxylesterase Vitellogenin chemistry.chemical_compound Biochemistry chemistry biology.protein Ecotoxicology Animal Science and Zoology Biomarkers of exposure assessment Xenobiotic Phase I Detoxification Ecology Evolution Behavior and Systematics |
| Zdroj: | Applied Herpetology. 2:335-353 |
| ISSN: | 1570-7547 |
| DOI: | 10.1163/1570754054507433 |
| Popis: | Biochemical biomarkers respond to a variety of environmental stresses, in particular to xenobiotic contamination. Their use in amphibian ecotoxicology has been scarce, and only in recent years have they been applied in a few cases of environmental monitoring. The best described biomarkers of xenobiotic effect in anurans are: the Cytochrome P450 enzymes which are induced in Phase I detoxification by a broad range of compounds; glutathione depletion and glutathione-S-Transferase induction by oxidative stress; vitellogenin induction by xenoestrogenic compounds causing feminization; acetylcholinesterase and carboxylesterase inactivation or inhibition by exposure to organophosphorus and carbamate compounds; and metallothioneins induced by exposure to toxic metals. As for other aquatic organisms, the integrated use of biochemical biomarkers seems the viable option for amphibian exposure and risk evaluations. |
| Databáze: | OpenAIRE |
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