Distribution of the total quantity of fatty acid double bonds in lipid components of the blood in children with diabetes mellitus
| Autor: | Sapelkina Lv, Marchenko Lf, Turkina Ti, Pozniak Ti, Kiseleva Ev |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
Degree of unsaturation medicine.medical_specialty Triglyceride business.industry Endocrinology Diabetes and Metabolism Fatty acid medicine.disease Ketoacidosis chemistry.chemical_compound Blood serum Endocrinology chemistry Internal medicine Diabetes mellitus Distribution (pharmacology) Medicine Decompensation business |
| Zdroj: | Problems of Endocrinology. 40:6-8 |
| ISSN: | 2308-1430 0375-9660 |
| Popis: | Children suffering from insulin-dependent diabetes mellitus (IDDM) were examined for unsaturation, that is, total quantity of double bonds in individual fractions of blood serum lipids was assessed. Lipid fractions were isolated by thin-layer chromatography. Unsaturation was assessed by ozonation method. The research was aimed at elucidation of biochemical criteria of the degree of metabolic disorders in children with IDDM and at development of methods for quantitative assessment of such disorders. Thirty-two inpatients with IDDM aged 7 to 15 were examined over time. Control group included 10 healthy age-matched children. Twenty children were examined during compensation stage (group 1), twelve during decompensation with ketoacidosis (group 2). Total unsaturation parameters were found reliably decreased in children with IDDM both during compensation and decompensation stages vs. those in healthy controls. A relative decrease of unsaturated fatty acids in the fraction of uneterified fatty acids (p0.05) was characteristic of group 2, with the content of their fragments in triglyceride fraction being the maximal (p0.05). The pattern of total unsaturation distribution in serum lipid fractions may serve as an indicator for metabolic disorders and decompensation in IDDM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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