Hipertrigliceridemia familiar/hipertrigliceridemia poligénica
| Autor: | José María Mostaza, Carlos Lahoz |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Very low-density lipoprotein
business.industry 030204 cardiovascular system & hematology Quantitative trait locus medicine.disease Bioinformatics Familial hypertriglyceridemia 03 medical and health sciences 0302 clinical medicine medicine Acute pancreatitis Pharmacology (medical) 030212 general & internal medicine Cardiology and Cardiovascular Medicine business |
| Zdroj: | Clínica e Investigación en Arteriosclerosis. 33:37-42 |
| ISSN: | 0214-9168 |
| DOI: | 10.1016/j.arteri.2020.12.014 |
| Popis: | For decades, familial hypertriglyceridemia (HTG) has been considered a specific entity characterized by an increase in VLDL particles and an autosomal dominant inheritance pattern. In the genomics era, it has been proven that familial HTG, although it could be grouped in families, had a polygenic inheritance in which the phenotype would be determined by concomitant environmental factors. Hence its inclusion in the group of polygenic HTGs. Clinically, they are characterized by moderate HTG, with the consequent increase in cardiovascular risk, and in rare cases, by severe HTG with risk of acute pancreatitis. Treatment will be based on controlling environmental factors, implementing hygienic-dietetic measures and sometimes drugs, to reduce cardiovascular risk in moderate HTGs and acute pancreatitis risk in severe HTGs. |
| Databáze: | OpenAIRE |
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