Identification of miRSNPs associated with the risk of multiple myeloma
| Autor: | Joaquin Martinez Lopez, Katalin Kadar, Agnieszka Druzd-Sitek, Asta Försti, Judit Várkonyi, Marzena Watek, Gabriele Buda, Małgorzata Raźny, Malgorzata Krawczyk-Kulis, Stefano Landi, Hartmut Goldschmidt, María Eugenia Sarasquete, Krzysztof Jamroziak, Kari Hemminki, Diego Calvetti, Matteo Pelosini, Ulla Vogel, Juan Sainz, Angelica Macauda, Mario Petrini, Andres Jerez, Charles Dumontet, Arnon Nagler, Marcin Rymko, Richard S. Houlston, Elżbieta Iskierka-Jażdżewska, Olga Ostrovsky, Anna Sureda, Gergely Szombath, Herlander Marques, Katia Beider, Federica Gemignani, Dominik Chraniuk, Fabienne Lesueur, Edyta Subocz, Artur Jurczyszyn, Anna Stępień, Victor Moreno, Ramón García Sanz, Grzegorz Mazur, Federico Canzian, Jan Maciej Zaucha, Marek Dudziński, Waldemar Tomczak, Giuseppe Maccari, Annette Juul Vangsted, Hervé Avet-Loiseau, Vibeke Andersen, Norbert Grząśko, Rui Manuel Reis, Marcin Kruszewski, Aleksandra Butrym, Daria Zawirska, Niels Weinhold, Svend Erik Hove Jacobsen, Janusz Hałka |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics Cancer Research education.field_of_study Population Case-control study Genome-wide association study Context (language use) Single-nucleotide polymorphism Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Genetic predisposition Population study SNP education |
| Zdroj: | International Journal of Cancer. 140:526-534 |
| ISSN: | 0020-7136 1419-1881 |
| Popis: | Multiple myeloma (MM) is a malignancy of plasma cells usually infiltrating the bone marrow, associated with the production of a monoclonal immunoglobulin (M protein) which can be detected in the blood and/or urine. Multiple lines of evidence suggest that genetic factors are involved in MM pathogenesis, and several studies have identified single nucleotide polymorphisms (SNPs) associated with the susceptibility to the disease. SNPs within miRNA-binding sites in target genes (miRSNPs) may alter the strength of miRNA-mRNA interactions, thus deregulating protein expression. MiRSNPs are known to be associated with risk of various types of cancer, but they have never been investigated in MM. We performed an in silico genome-wide search for miRSNPs predicted to alter binding of miRNAs to their target sequences. We selected 12 miRSNPs and tested their association with MM risk. Our study population consisted of 1,832 controls and 2,894 MM cases recruited from seven European countries and Israel in the context of the IMMEnSE (International Multiple Myeloma rESEarch) consortium. In this population two SNPs showed an association with p |
| Databáze: | OpenAIRE |
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