Роль ентеропатогенних кишкових паличок у розвитку і перебігу хронічного невиразкового коліту
| Autor: | I. Y. Sydorchuk, D. V. Rotar, A.V. Humenna, L. I. Sydorchuk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Nosology
Serotype biology business.industry Disease medicine.disease biology.organism_classification Ulcerative colitis Persistence (computer science) 03 medical and health sciences Agglutination (biology) 0302 clinical medicine Escherichia Immunology medicine 030211 gastroenterology & hepatology Colitis business 030215 immunology |
| Zdroj: | GASTROENTEROLOGY. :33-37 |
| ISSN: | 2518-7880 2308-2097 |
| Popis: | Objective. The analysis of the literature has shown that in patients with chronic non-ulcerative colitis, there were isolated E.coli that cause dysentery-like, cholera-like diseases and escherichioses. Thus, the aim of our study was to establish the level of persistence of enteropathogenic Escherichia in the colon of patients with chronic non-ulcerative colitis and their importance in the ecological system «macroorganism — microbiota». Material and methods. During 2000–2015, there has been conducted a bacteriological examination of the colon content in patients with chronic non-ulcerative colitis aged 27–41 years (average age 37.74 ± 3.62 years). The resulting cultures were examined in the indicative agglutination tests with OKA polyvalent serum. Positive cultures were tested with polyvalent serum of narrow spectrum ОКВ, ОКС, ОКD and ОКЕ. Results. In patients, in colon cavity of which E.coli O18ac:K77; O26:K60; O55:K59; O128ab:K67 were detected, the disease occurs by nosology of colienteritis. In those patients, in whom O25:K11; O144:K; O124:K72 serotypes have been identified, disease occurred as bacterial dysentery, and O25:K11 and O128:K67 — in cholera-like form. Discussion. In 94.50 % of patients, common E.coli were detected, but in 55 (35.03 %) of them enteropathogenic Escherichia persist, in 41 (26.11 %) — E.coli Hly+, in 37 (23.57 %) — E.coli Lac–, in 18 (11.46 %) — enterotoxigenic E.coli, in 14 (8.42 %) — enteroinvasive, and in 11 (7.01 %) — enterohemorragic Escherichia. Conclusions. It was determined that the main serotypes of opportunistic Escherichia, which colonize and persist in the colon cavity of patients with chronic non-ulcerative colitis, were O114:K90; O25:K11; O124:K72; O128:K67; O18ac:K77, the persistence of which affects clinical manifestation from colitis to dysentery-like or cholera-like disease. |
| Databáze: | OpenAIRE |
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