Asymmetric [1,3]-dipolar cycloaddition reactions: synthesis of highly substituted proline derivatives

Autor:	Weixu Zhai, David J. Aldous, S. C. Aldous, Robert M. Williams
Rok vydání:	1992
Předmět:	chemistry.chemical_classification chemistry Stereochemistry Organic Chemistry 1 3-Dipolar cycloaddition Azomethine ylide Proline Tricarboxylic acid Ring (chemistry) Cycloaddition Stereocenter
Zdroj:	The Journal of Organic Chemistry. 57:6527-6532
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo00050a029
Popis:	The asymmetric [1,3]-dipolar cycloaddition reactions of azomethine ylides derived from (SR,6S)-2,3,5,6-tetrahydro-5,6-diphenyl-1,4-oxazin-2-one with various aldehydes and methyl maleate is described. The reactions prove to be highly endo-selective, installing three contiguous stereogenic centers in the newly formed five-membered ring with essentially complete stereochemical control
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d1f44d8f35324017a8a4c1a4f5314ecc https://doi.org/10.1021/jo00050a029 Zobrazit plný text záznamu