| Popis: |
Apoptosis is an integral part of normal mammary gland development, differentiation, and function. Numerous descriptive and mechanistic studies of programmed cell death pathways in normal and malignant mammary cells have been presented. This chapter reviews the evidence that established breast cancer treatments act via apoptotic pathways, and how ongoing laboratory work defining these pathways might lead to the development of new therapeutic ap proaches. Also, the possibility that evaluation of apoptotic-related molecules or events might serve as prognostic or predictive factors is discussed. |
