Iron Does Not Cause Arrhythmias in the Guinea Pig Model of Transfusional Iron Overload
| Autor: | George Bohart, John M. Davis, Kenneth A. Schwartz, Jon S. Patterson, N. Bari Olivier, Lana Kaiser |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
education.field_of_study biology business.industry Thalassemia Immunology Population Caviidae Cell Biology Hematology biology.organism_classification medicine.disease Biochemistry Guinea pig Internal medicine Heart failure cardiovascular system Cardiology Medicine In patient cardiovascular diseases Iron Dextran Complex business education Cause of death |
| Zdroj: | Blood. 108:3724-3724 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v108.11.3724.3724 |
| Popis: | Cardiac events, including heart failure and arrhythmias, are the major cause of death in patients with b-thalassemia. Although cardiac arrhythmias in humans are believed to result from iron overload, excluding confounding factors in the human population is difficult. The purpose of these studies was to evaluate the development of cardiac arrhythmias using the guinea pig model of secondary iron overload. Electrocardiograms were recorded via surgically implanted telemetry devices in guinea pigs loaded intraperitoneally with iron dextran and controls. Cardiac and liver iron concentrations were significantly elevated in the iron loaded animals when compared to control, and were in the range of those reported for humans with thalassemia. Arrhythmias were noted infrequently in both iron loaded and control guinea pigs. No life threatening arrhythmias were detected in either group. These data suggest that iron alone may be insufficient to cause cardiac arrhythmias, and that arrhythmias detected in individuals with iron overload may be the result of a complex interplay of factors. |
| Databáze: | OpenAIRE |
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