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The envelope glycoproteins mediate important aspects of host-virus ships and lentivirus pathogenic properties: they govern the cell tr interacting at the cell membrane with cellular receptors, they membrane fusion to allow virus entry, and they constitute a major the immune response. In the case of HIV-1, as well as that lentiviruses, comparisons of amino acid sequences among variou isolates have shown that envelope glycoproteins consist of a succession of variable domains which are bordered by conserved domains, most likely determining a conserved spatial framework organization (Alizon et al. 1986; Myers et al. 1990). |
