History of Infection Prior to Hematopoietic Stem Cell Transplant in the Recipient as a Risk Factor to Develop Acute Graft versus Host Disease
| Autor: | Nideshda Ramírez-Uribe, Iván Castorena-Villa, Gerardo López-Hernández, Martín Pérez-García, Haydeé Salazar-Rosales, Alberto Olaya-Vargas |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Hematopoietic stem cell Retrospective cohort study Hematopoietic stem cell transplantation Disease Gastroenterology surgical procedures operative medicine.anatomical_structure immune system diseases hemic and lymphatic diseases Allogeneic hsct Internal medicine Acute graft versus host disease medicine Bone marrow Risk factor business |
| Zdroj: | Journal of Cancer Therapy. 10:327-335 |
| ISSN: | 2151-1942 2151-1934 |
| Popis: | Background: Acute graft-versus-host disease (aGVHD) is the most frequent and severe complication after allogeneic hematopoietic stem cell transplantation (HSCT). Objective: To determine if a history of prior infection in the allogeneic HSTC recipient is a risk factor to develop aGVHD. Methods: A retrospective cohort study based on data collected from the Department of Hematopoietic Stem Cell Transplantation at the Instituto Nacional de Pediatria (INP) from January 1998 to December 2016 was performed to identify if prior infection was a predictive risk factor for aGVHD. Results: 27 patients developed aGVHD (36.4%). Median time to aGVHD presentation was 82 days (9 to 273 days). Most patients developed grade III aGVHD. Following the multivariate analysis peripheral blood > bone marrow (OR 12.3; p 8.3 × 106/kg (OR 7.1; p = 0.05), peripheral blood (OR: 11.4; p < 0.001), infection 3 months prior to allogeneic transplant (OR: 4.5; p < 0.03) and CMV infection in the recipient (OR: 4.68; p < 0.03) were significant. Conclusions: Either bacterial infection or CMV infection in the recipient was significant risk factor within the aGVHD recipients; it is important to consider these factors for patients that are going to receive an allogeneic HSCT. |
| Databáze: | OpenAIRE |
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