Roxithromycin Treatment in Patients with Chronic Lower Respiratory Tract Disease
| Autor: | K. Iida, Kohei Hara, Koh Abe, Ryo Shirai, Shiro Kusano, Kaoru Kawakami, Toru Morikawa, Shigeru Kohno, Jun-ichi Kadota, Osamu Sakito |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry medicine.medical_treatment Roxithromycin General Medicine Respiratory tract disease medicine.disease Gastroenterology Cytokine Bronchoalveolar lavage Internal medicine medicine In patient Clinical efficacy Interleukin 8 business Diffuse panbronchiolitis medicine.drug |
| Zdroj: | Journal of the Japanese Association for Infectious Diseases. 68:27-33 |
| ISSN: | 1884-569X 0387-5911 |
| DOI: | 10.11150/kansenshogakuzasshi1970.68.27 |
| Popis: | We demonstrated the efficacy of "long term" roxithromycin (RXM) treatment in 15 patients with chronic lower respiratory tract disease (11 with diffuse panbronchiolitis and 4 with sinobronchial syndrome). (1) Fourteen (93.3%) of the 15 patients showed improvement when assessed by the comprehensive improvement score, and they showed significant improvements in PaO2 (74.2 +/- 10.4 Torr to 84.3 +/- 10.9 Torr, p < 0.01), %VC (86.9 +/- 20.2% to 96.0 +/- 21.9%, p < 0.001) and FEV1 (1.81 +/- 0.87 L to 2.14 +/- 1.08 L, p < 0.01) after RXM treatment. (2) Neutrophils accumulated in the pre-RXM treatment bronchoalveolar lavage (BAL) fluid and decreased in BAL fluid of patients responding to RXM treatment (49.8 +/- 28.3% to 17.1 +/- 15.7%, p < 0.01). Additionally, the levels of interleukin 1 beta and interleukin 8 were significantly higher in BAL fluid of these patients than those in the healthy volunteers (p < 0.025, p < 0.01 respectively), and correlated with the neutrophil accumulation (r = 0.619, p < 0.05). These cytokines showed a decrease after RXM treatment. These results indicated that RXM acts by reducing pulmonary inflammation through reduction of neutrophil migration to inflammatory sites, and is effective on chronic lower respiratory tract disease. |
| Databáze: | OpenAIRE |
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