Thiols, unsymmetrical sulfides and thioacetals from the new reagent: Triisopropylsilanethiol

Autor:	Michael J. Diaz, Edgar I. Miranda, Izander Rosado, John A. Soderquist
Rok vydání:	1994
Předmět:	chemistry.chemical_classification chemistry Potassium Reagent Yield (chemistry) Organic Chemistry Drug Discovery Halide chemistry.chemical_element Organic chemistry Alkylation Biochemistry Alkyl
Zdroj:	Tetrahedron Letters. 35:3221-3224
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)76869-9
Popis:	Triisopropylsilanethiol (HSTIPS, 1 ), easily prepared in 98% yield from H 2 S and TIPSCl, is efficiently alkylated in a selective manner with 1° and 2° alkyl halides or tosylates through its potassium thiolate ( 2c ) to provide RSTIPS ( 3 ) in excellent yields. Compound 3 provides a convenient source of alkanethiols ( 4 ), unsymmetrical dialkyl sulfides ( 5 ) and thioacetals ( 6 ).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d1bcfd2bb2787da9ec4992c773b87abf https://doi.org/10.1016/s0040-4039(00)76869-9 Zobrazit plný text záznamu