Comparison of the effects of propofol and sevoflurane on postoperative cognitive functions and memory in patients undergoing general anaesthesia

Autor: Pragna N. Vachhrajani, Richa Mukeshbhai Tailor, Malti J Pandya
Rok vydání: 2019
Předmět:
Zdroj: Indian Journal of Clinical Anaesthesia. 6:559-564
ISSN: 2394-4994
2394-4781
DOI: 10.18231/j.ijca.2019.109
Popis: This study finds out the effect of propofol and sevoflurane on cognitive function and memory and also compare s the effect on postoperative recovery profile in patients undergoing general anaesthesia. Aim of the study is to compare the effects of propofol and sevoflurane on cognitive and memory function in terms of psychometric test pre and post general anaesthesia. 60 patients of age group 18– 60 years and ASA grade I, II, III scheduled for general anesthesia were included in this study. Patients were divided into two groups in maintenance : group P: Inj. propofol infusion and group S: sevoflurane. Assessment of cognitive function and memory of patients in both groups was done preoperatively by following Materials and Methods: MMSE score, CVLT, DST, RBMT and Recalling the names of surgeon and anaesthetist. After extubation, Patients were observed for recovery by alderate recovery score up to 1 hour and assessed for pain by visual analogue scale up to 4 hours postoperatively. C ognitive function and memory up to 4 h ours was assessed postoperatively. The recovery characteristics were better with sevoflurane than propofol up to 10 mins. Sevoflurane had less impact on cognitive function as compared to propofol up to 30 mins postoperative. Effect on verbal and numerical memory was less with sevoflurane as compared to propofol up to 30 mins. Effect on semantic memory was less with sevoflurane as compared to propofol up to 5 mins except recall memory. We concluded from above study that when rapid recovery of cognitive function and memory are desired, sevoflurane is more favourable than propofol for a faster recovery and emergence from anaesthesia. Keywords: Propofol, Sevoflurane, Cognitive function, Memory.
Databáze: OpenAIRE
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