Stereotactic Body Radiation Therapy (SBRT) using Intensity Modulation for Spine and Paraspinal Lesions: A Planning Comparison of RapidArc and Helical Tomotherapy
| Autor: | H.L. Lee, N.E. Dunlap, J. Cai, W. Yang, S.H. Benedict, P.W. Read, J.M. Larner |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Cancer Research
medicine.medical_specialty Radiation Stereotactic body radiation therapy business.industry medicine.medical_treatment Planning target volume Spinal cord Tomotherapy Treatment efficacy Target dose Lumbar medicine.anatomical_structure Oncology medicine Radiology Nuclear Medicine and imaging Radiology business Intensity modulation |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 75:S238-S239 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2009.07.549 |
| Popis: | Purpose/Objective(s): Spinal SBRT is an effective palliative option for treating spinal and paraspinal lesions in order to provide rapid and durable pain relief. Volumetric arc-based intensity modulated radiation therapy (IMRT) has previously been shown to improve target dose distribution and normal tissue sparing compared to conventional fixed gantry IMRT using standard fractionation. Both RapidArc (RA) and helical TomoTherapy (HT) represent IMRT-based treatment modalities integrated within an arc geometry. The potential dosimetric benefits and limitation of SBRT were compared between RA and HT. Materials/Methods: Eight patients with spine and paraspinal lesions (2 cervical, 4 thoracic, and 2 lumbar lesions) previously treated on HT in accordance with an institutional protocol for SBRT were reviewed. Comparison plans were generated using a volumetric single arc (Varian RapidArc). Plans were prescribed 24 Gy in 3 fractions to cover 95% of the planning target volume (PTV). The adjacent spinal cord was defined by MRI fusion to include 6mm above and below the PTV. Plans were analyzed in terms of conformality index (CI100%), homogeneity index (HI), minimum significant target dose (D99%), maximum significant target dose (D1%), and doses to organs at risk (OARs). Conformality index assessment was based on the RTOG 0813 protocol for lung SBRT. All planning attempts were made to limit the maximum point dose to the spinal cord dose to |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|