Fungal P450 monooxygenases - the diversity in catalysis and their promising roles in biocontrol activity
Autor: | Razak Hussain, Mushtaq Ahmed, Tabreiz Ahmad Khan, Yusuf Akhter |
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Rok vydání: | 2019 |
Předmět: |
0303 health sciences
Plant growth Primary (chemistry) 030306 microbiology Mechanism (biology) Trichothecene General Medicine Computational biology Monooxygenase Biology Applied Microbiology and Biotechnology Genome 03 medical and health sciences Functional studies Secondary metabolism 030304 developmental biology Biotechnology |
Zdroj: | Applied Microbiology and Biotechnology. 104:989-999 |
ISSN: | 1432-0614 0175-7598 |
Popis: | The fungal P450s catalyze vital monooxygenation reactions in primary and secondary metabolism, which may lead to the production of diverse secondary metabolites. Many of these, such as from the family of trichothecenes, involve in biocontrol activities. The diversified nature of fungal P450 monooxygenases makes their host organisms adoptable to various ecological niches. The available genome data analysis provided an insight into the activity and mechanisms of the fungal P450s. However, still more structural and functional studies are needed to elucidate the details of its catalytic mechanism, and the advance studies are also required to decipher further about their dynamic role in various aspects of trichothecene oxygenations. This mini review will provide updated information on different fungal P450 monooxygenases, their genetic diversity, and their role in catalyzing various biochemical reactions leading to the production of plant growth promoting secondary metabolites. |
Databáze: | OpenAIRE |
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