Calcium and 25-Hydroxyvitamin D3 Binding Proteins in Human Placenta

Autor:	Gray Tk, Williams Me, Fowler Sa
Rok vydání:	1978
Předmět:	Molecular mass chemistry.chemical_element Chromosomal translocation Calcium Biology Cytosol Column chromatography medicine.anatomical_structure Biochemistry chemistry Cytoplasm Placenta Pediatrics Perinatology and Child Health medicine Ultracentrifuge Developmental Biology
Zdroj:	Neonatology. 33:8-12
ISSN:	1661-7819 1661-7800
Popis:	The placental translocation of calcium is a well-known process, but the underlying mechanisms remain unknown. Placental cytoplasmic proteins capable of binding calcium and the active metabolites of vitamin D3 were sought in these studies. Cytosol from full-term human placenta was prepared by ultracentrifugation of homogenates and tested for binding. Partial purification by column chromatography revealed the presence of two discrete proteins which bound specifically 45Ca and 3H-25-hydroxyvitamin D3 and having approximate molecular weights of 12,000 and 67,000, respectively. These placental proteins may be intermediaries in the process of placental calcium translocation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d1a3bd08810fcb32090bf0580560d943 https://doi.org/10.1159/000241044 Zobrazit plný text záznamu