(±)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-methyl-5-aryl-2-penten-4-ynyl) oximes: Potent muscarinic agonists

Autor:	R.D. Schwan, Anthony Jerome Thomas, D.W. Moreland, Haile Tecle, Juan C. Jaen, T. Mirzadegan, Lauffer David Jeffrey, Charlotte Raby, David Eubanks, Mark R. Brann, Robert E. Davis
Rok vydání:	1995
Předmět:	Stereochemistry Aryl Organic Chemistry Clinical Biochemistry Pharmaceutical Science Oxime Biochemistry chemistry.chemical_compound chemistry Drug Discovery Muscarinic acetylcholine receptor Molecular Medicine Potency Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:637-642
ISSN:	0960-894X
DOI:	10.1016/0960-894x(95)00087-a
Popis:	Synthesis and SAR of a new class of 1-azabicyclo[2.2.1]heptan-3-one, O-(3-methyl-5-aryl-2-penten-4-ynyl) oxime muscarinic agonists are described. Depending on the geometry of the C=N and C=C bonds, subnanomolar potency and/or high efficacy are achieved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d19db98ce421d0af342857b2b965ea7f https://doi.org/10.1016/0960-894x(95)00087-a Zobrazit plný text záznamu Full Text from ScienceDirect