Glucosamine-based phosphines. Efficient ligands in the Suzuki cross-coupling reaction in water

Autor:	Catherine Goux-Henry, Robert Kolodziuk, Alexander Iourtchenko, Denis Sinou, Sophie Parisot
Rok vydání:	2002
Předmět:	Organic Chemistry Carbohydrate Biochemistry Medicinal chemistry Coupling reaction Catalysis chemistry.chemical_compound Water soluble Suzuki reaction chemistry Glucosamine Drug Discovery Organic chemistry Benzoic acid
Zdroj:	Tetrahedron Letters. 43:7397-7400
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(02)01749-5
Popis:	Coupling of protected or non-protected d -glucosamine with o - or p -(diphenylphosphino)benzoic acid generates carbohydrate-substituted phosphines in quite good yields. The catalytic performance of these new neutral ligands is demonstrated in the Suzuki cross-coupling reaction. The polyhydroxy phosphines are more active than the peracetylated phosphines, and the process tolerates electron-rich as well as electron-poor substituents. Excellent turnovers are observed, and the catalyst can be recycled.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d186217b6b250d16d9e77012b5dcb7a9 https://doi.org/10.1016/s0040-4039(02)01749-5 Zobrazit plný text záznamu Full Text from ScienceDirect