ChemInform Abstract: An Anion-Induced Regio- and Chemoselective Acylation and Its Application to the Synthesis of an Anticancer Agent

Autor:	Bernard Charles F, Frank Xing Chen, YeeShing Wong, Marc Poirier, George G. Wu
Rok vydání:	2010
Předmět:	Acylation Steric effects chemistry.chemical_compound Chemistry Reagent General Medicine Grignard reagent Anisole Combinatorial chemistry Ion
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200213153
Popis:	[reaction--see text] An efficient Grignard- and organolithium-induced regio- and chemoselective anionic acylation is reported. A number of tricyclic ketones are prepared in good to excellent yields via this method. This method is complementary to the Frieldel-Crafts acylation for electron-deficient substrates. A novel anisole-based Grignard reagent was developed to effect the cyclization of sterically hindered substrates. This novel reagent has been successfully applied to the synthesis of Sch 66336, a candidate for oncologic treatment.
Databáze:	OpenAIRE
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