Hyperpolarized 3He magnetic resonance imaging: Preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease
| Autor: | Andrew Wheatley, Roya Etemad-Rezai, David G. McCormack, Lindsay Mathew, Grace Parraga, Miranda Kirby |
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| Rok vydání: | 2011 |
| Předmět: |
Spirometry
Pathology medicine.medical_specialty COPD Lung medicine.diagnostic_test business.industry Respiratory disease Magnetic resonance imaging General Medicine Airway obstruction medicine.disease medicine.anatomical_structure medicine Plethysmograph Effective diffusion coefficient Radiology Nuclear Medicine and imaging Nuclear medicine business |
| Zdroj: | European Journal of Radiology. 79:140-146 |
| ISSN: | 0720-048X |
| Popis: | Rationale and objectives Emphysema and small airway obstruction are the pathological hallmarks of chronic obstructive pulmonary disease (COPD). The aim of this pilot study in a small group of chronic obstructive pulmonary disease (COPD) patients was to quantify hyperpolarized helium-3 ( 3 He) magnetic resonance imaging (MRI) functional and structural measurements and to explore the potential role for 3 He MRI in detecting the lung structural and functional COPD phenotypes. Materials and methods We evaluated 20 ex-smokers with stage I ( n = 1), stage II ( n = 9) and stage III COPD ( n = 10). All subjects underwent same-day plethysmography, spirometry, 1 H MRI and hyperpolarized 3 He MRI at 3.0 T. 3 He ventilation defect percent (VDP) was generated from 3 He static ventilation images and 1 H thoracic images and the 3 He apparent diffusion coefficient (ADC) was derived from diffusion-weighted MRI. Results Based on the relative contribution of normalized ADC and VDP, there was evidence of a predominant 3 He MRI measurement in seven patients ( n = 3 mainly ventilation defects or VDP dominant (VD), n = 4 mainly increased ADC or ADC dominant (AD)). Analysis of variance (ANOVA) showed significantly lower ADC for subjects with predominantly elevated VDP ( p = 0.02 compared to subjects with predominantly elevated ADC; p = 0.008 compared to mixed group) and significantly decreased VDP for subjects with predominantly elevated ADC ( p = 0.003, compared to mixed group). Conclusion In this small pilot study, a preliminary analysis shows the potential for 3 He MRI to categorize or phenotype COPD ex-smokers, providing good evidence of feasibility for larger prospective studies. |
| Databáze: | OpenAIRE |
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