| Autor: |
Patricia G. Webb, Palaniappian Ramanathan, Akihiro Kamikawa, Margaret C. Neville |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Ion Transport Across Epithelial Tissues and Disease ISBN: 9783030553098 |
| DOI: |
10.1007/978-3-030-55310-4_6 |
| Popis: |
Membrane transporters are essential for the synthesis and secretion of milk. We are at a transition point; in the twentieth century, most transport studies were carried out by following the transported molecule into the cell and examining all the ways that transport could be perturbed by the environment, allowing functional descriptions of most transport processes. We now have powerful molecular tools so that the molecular nature of the transporters as well as the mRNAs from which they are transcribed can be studied; in addition, antibodies to the proteins allow the transporters to be localized within the cell so that real cellular pathways can be discerned. So that our current knowledge can be of most use to the scientific community we use mRNA expression levels from two datasets representing complete catalogues of expressed genes in the lactating mammary gland of the human and the mouse. These expression levels are compared with expression levels in the colostral and transitional milk phases in the case of human milk and with midpregnancy expression levels in the mouse. The data provide a molecular framework, which should greatly facilitate future elucidation of transporters and their function in the cellular compartments involved in the secretion of milk. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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