The role of natural and UV-induced skin pigmentation on low-fluence IPL-induced side effects: A randomized controlled trial
| Autor: | Merete Haedersdal, Frank Beerwerth, Peter A. Philipsen, Daniel Thaysen-Petersen, Jennifer Y. Lin, Jf Nash, Hans Christian Wulf |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
integumentary system medicine.diagnostic_test Skin type Erythema business.industry medicine.medical_treatment Blisters Dermatology Intense pulsed light law.invention Randomized controlled trial law Biopsy Hair removal Medicine Surgery sense organs medicine.symptom business Adverse effect |
| Zdroj: | Lasers in Surgery and Medicine. 46:104-111 |
| ISSN: | 0196-8092 |
| DOI: | 10.1002/lsm.22167 |
| Popis: | Background and Objectives The risk of adverse skin effects following light-based hair removal is greater in pigmented skin based on the theory of selective photothermolysis. Thus sunlight-induced pigment i.e., facultative pigmentation, increases the risk of adverse skin effects, perhaps disproportionately. The aim of this study was to evaluate the influence of constitutive and facultative skin pigmentation on low-fluence intense pulsed light (IPL)-induced adverse skin effects. Study Design/Materials and Methods Twenty-one subjects with Fitzpatrick skin type II–IV were enrolled. Two buttock blocks were randomized to receive 0 or 8 solar simulated ultraviolet radiation (UVR) exposures of consecutively increasing Standard Erythema Doses (2–4 SED). Each block was subdivided into four sites, randomized to receive IPL of 0, 7, 8, or 10 J/cm2, once a week for 3 weeks. Biopsies were taken 16–24 hours after the first IPL exposure and subjects were seen 1 and 4 weeks after the last IPL exposure. Outcome measures were: (i) skin reactions, (ii) pain, (iii) mRNA expression of pigment-markers microphthalmia-associated transcription factor (MITF) and pro-opiomelanocortin (POMC), and (iv) clinical appearance of biopsy wounds. Results Skin pigmentation increased after UVR (baseline median 13.8%, after UVR 28.1%, P = 0.0001) in all skin types. Subjects reported low pain intensities (median 1.5, scale 0–10) and experienced transient erythema immediately after IPL exposure. No persistent erythema, blisters, crusting, textual, or pigment changes were observed. The risk of erythema and pain intensities increased with IPL dose and skin pigmentation (P |
| Databáze: | OpenAIRE |
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