A comparison of propofol infusion and propofol/isoflurane anaesthesia in dexmedetomidine premedicated dogs
| Autor: | Outi Vainio, Erja Kuusela, Marja Raekallio, C. E. Short, A. Valtonen, S. Ström, Pirkko Huttunen, Juhani Leppäluoto, V. Huju |
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| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
General Veterinary 040301 veterinary sciences business.industry Cold pressor test 04 agricultural and veterinary sciences 3. Good health 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Isoflurane 030202 anesthesiology Anesthesia Heart rate medicine Arterial blood Premedication Respiratory system Dexmedetomidine business Propofol medicine.drug |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 26:199-204 |
| ISSN: | 0140-7783 |
| DOI: | 10.1046/j.1365-2885.2003.00465.x |
| Popis: | The effects of propofol infusion were compared with propofol/isoflurane anaesthesia in six beagles premedicated with 10 microg/kg intramuscular (i.m.) dexmedetomidine. The suitability of a cold pressor test (CPT) as a stress stimulus in dogs was also studied. Each dog received isoflurane (end tidal 1.0%, induction with propofol) with and without CPT; propofol (200 microg/kg/min, induction with propofol) with and without CPT; premedication alone with and without CPT in a randomized block study in six separate sessions. Heart rate and arterial blood pressures and gases were monitored. Plasma catecholamine, beta-endorphin and cortisol concentrations were measured. Recovery profile was observed. Blood pressures stayed within normal reference range but the dogs were bradycardic (mean heart rate 57 mmHg) when compared with isoflurane (mean < 52 mmHg). Recovery times were longer with propofol than when compared with the other treatments. The mean extubation times were 8 +/- 3.4 and 23 +/- 6.3 min after propofol/isoflurane and propofol anaesthesia, respectively. The endocrine stress response was similar in all treatments except for lower adrenaline level after propofol infusion at the end of the recovery period. Cold pressor test produced variable responses and was not a reliable stress stimulus in the present study. Propofol/isoflurane anaesthesia was considered more useful than propofol infusion because of milder degree of respiratory depression and faster recovery. |
| Databáze: | OpenAIRE |
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