Tachykinin NK1 and NK2 receptors mediate inhibitory vs excitatory motor responses in human isolated corpus cavernosum and spongiosum
| Autor: | Guido Barbagli, Enzo Palminteri, Massimo Lazzeri, Riccardo Patacchini, Carlo Alberto Maggi, Damiano Turini |
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| Rok vydání: | 2002 |
| Předmět: |
Pharmacology
medicine.medical_specialty musculoskeletal neural and ocular physiology Antagonist Biology Motor neuron Sulfone chemistry.chemical_compound Endocrinology Muscle relaxation medicine.anatomical_structure Corpus Spongiosum chemistry Internal medicine medicine Neurokinin A medicine.symptom Tachykinin receptor Muscle contraction |
| Zdroj: | British Journal of Pharmacology. 135:1351-1354 |
| ISSN: | 0007-1188 |
| DOI: | 10.1038/sj.bjp.0704650 |
| Popis: | Motor effects produced by tachykinins were studied in human isolated corpus spongiosum and cavernosum. In quiescent preparations neurokinin A caused potent contractions (pD2=8.3 – 7.9 respectively) prevented by the NK2 receptor-selective antagonist nepadutant, whereas [Sar9]SP sulfone and senktide (NK1 and NK3 receptor-selective agonists) produced no effect or spare contractions. In KCl-precontracted corpus spongiosum septide (pD2=7.1) and [Sar9]SP sulfone (pD2=7.7) produced tetrodotoxin-resistant relaxations, abolished by the tachykinin NK1 receptor-selective antagonist SR 140333. [Sar9]SP sulfone (1 μM) produced similar relaxations in precontracted corpus cavernosum. Electrical field stimulation (EFS) elicited tetrodotoxin-sensitive relaxations, which were additive to those produced by [Sar9]SP sulfone. Nω-nitro-L-arginine (L-NOARG) totally prevented both [Sar9]SP sulfone- and EFS-induced relaxations. These results show that tachykinin NK1 and NK2 receptors mediate opposite motor effects in human penile tissues, suggesting a possible modulatory role of tachykinins on smooth muscle tone in these organs. British Journal of Pharmacology (2002) 135, 1351–1354; doi:10.1038/sj.bjp.0704650 |
| Databáze: | OpenAIRE |
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