Fibroblast growth factors and pancreas organogenesis
| Autor: | E. P. Kopantsev, E. D. Sverdlov, D A Gnatenko |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
FGFR signaling pathway Clinical Biochemistry Mesenchymal stem cell Organogenesis Biology Fibroblast growth factor medicine.disease_cause Biochemistry Embryonic stem cell Cell biology 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure medicine Molecular Medicine Progenitor cell Pancreas Carcinogenesis |
| Zdroj: | Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 11:341-348 |
| ISSN: | 1990-7516 1990-7508 |
| DOI: | 10.1134/s1990750817040023 |
| Popis: | Fibroblast growth factors (FGFs) are growth factors that regulate many important biological processes, including proliferation and differentiation of embryonic cells during organogenesis. In this review, we have summarized current information about the role of FGFs in pancreas organogenesis. The pancreas organogenesis is a complex process, which involves constant signaling from mesenchymal tissue and activation of various genes regulating particular stages thus determining specification of progenitor cells. Changes in the FGF/FGFR signaling pathway during this process result in incorrect activation of master genes, leading to different pathologies in pancreas development. Understanding the full picture about the role of FGFs in pancreas development will help better understanding of their role in other pathologies of the pancres, including carcinogenesis. |
| Databáze: | OpenAIRE |
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