Association between markers of endothelial dysfunction and early signs of renal dysfunction in pediatric obesity and type 1 diabetes
| Autor: | I Di Giovanni, T. de Giorgis, M. L. Marcovecchio, Valentina Chiavaroli, Angelika Mohn, Francesco Chiarelli |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Renal function 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Internal Medicine medicine Endothelial dysfunction Type 1 diabetes Creatinine biology business.industry medicine.disease Obesity Endocrinology Cystatin C chemistry Myeloperoxidase Pediatrics Perinatology and Child Health biology.protein business Body mass index |
| Zdroj: | Pediatric Diabetes. 18:283-289 |
| ISSN: | 1399-543X |
| DOI: | 10.1111/pedi.12391 |
| Popis: | Background To evaluate whether circulating markers of endothelial dysfunction, such as intercellular adhesion molecule-1 (ICAM-1) and myeloperoxidase (MPO), are increased in youth with obesity and in those with type 1 diabetes (T1D) at similar levels, and whether their levels are associated with markers of renal function. Methods A total of 60 obese youth [M/F: 30/30, age: 12.5 ± 2.8 yr; body mass index (BMI) z-score: 2.26 ± 0.46], 30 with T1D (M/F: 15/15; age: 12.9 ± 2.4 yr; BMI z-score: 0.45 ± 0.77), and 30 healthy controls (M/F: 15/15, age: 12.4 ± 3.3 yr, BMI z-score: −0.25 ± 0.56) were recruited. Anthropometric measurements were assessed and a blood sample was collected to measure ICAM-1, MPO, creatinine, cystatin C and lipid levels. A 24-h urine collection was obtained for assessing albumin excretion rate (AER). Results Levels of ICAM-1 and MPO were significantly higher in obese [ICAM-1: 0.606 (0.460–1.033) µg/mL; MPO: 136.6 (69.7–220.8) ng/mL] and T1D children [ICAM-1: 0.729 (0.507–0.990) µg/mL; MPO: 139.5 (51.0–321.3) ng/mL] compared with control children [ICAM-1: 0.395 (0.272–0.596) µg/mL MPO: 41.3 (39.7–106.9) ng/mL], whereas no significant difference was found between T1D and obese children. BMI z-score was significantly associated with ICAM-1 (β = 0.21, p = 0.02) and MPO (β = 0.41, p |
| Databáze: | OpenAIRE |
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