EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development
| Autor: | Masaaki Torii, Kazue Hashimoto-Torii, Pasko Rakic, Alexander I. Son, Pat Levitt |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Neocortex General Neuroscience Erythropoietin-producing hepatocellular (Eph) receptor EPHA7 Biology EPH receptor B2 Receptor tyrosine kinase 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure EPH receptor A3 medicine biology.protein Ephrin Axon guidance Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Comparative Neurology. 524:2080-2092 |
| ISSN: | 0021-9967 |
| Popis: | Deciphering the molecular basis for guiding specific aspects of neocortical development remains a challenge because of the complexity of histogenic events and the vast array of protein interactions mediating these events. The Eph family of receptor tyrosine kinases is implicated in a number of neurodevelopmental activities. Eph receptors have been known to be capable of responding to several ephrin ligands within their subgroups, often eliciting similar downstream effects. However, several recent studies have indicated specificity between receptor-ligand pairs within each subfamily, the functional relevance of which is not defined. Here we show that a receptor of the EphA subfamily, EphA4, has effects distinct from those of its close relative, EphA7, in the developing brain. Both EphA4 and EphA7 interact similarly with corresponding ligands expressed in the developing neocortex. However, only EphA7 shows strong interaction with ligands in the somatosensory thalamic nuclei; EphA4 affects only cortical neuronal migration, with no visible effects on the guidance of corticothalamic (CT) axons, whereas EphA7 affects both cortical neuronal migration and CT axon guidance. Our data provide new evidence that Eph receptors in the same subfamily are not simply interchangeable but are functionally specified through selective interactions with distinct ligands in vivo. J. Comp. Neurol. 524:2080-2092, 2016. © 2015 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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