| Autor: |
Xueheng Zhao, Mark Messina, James E. Heubi, Eileen C. King, Stephanie L. Lindley, Kenneth D.R. Setchell, Nadine M Brown |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
The American Journal of Clinical Nutrition. 94:1284-1294 |
| ISSN: |
0002-9165 |
| DOI: |
10.3945/ajcn.111.019638 |
| Popis: |
Background: Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences in isoflavone metabolism. Objective: The objective of this study was to determine whether soy isoflavone phase II metabolism differs between humans and rodents. Design: Circulating total and unconjugated isoflavone concentrations were determined by mass spectrometry in plasma samples from 7 separate studies: 1) in Sprague-Dawley rats and in 3 strains of mice fed commercial soy-containing diets; 2) in Sprague-Dawley rats gavaged with genistein; 3) in healthy adults who consumed single servings of soy nuts, soy milk, and tempeh; 4) in healthy adults subchronically given soy milk; 5) in healthy women orally administered 50 mg genistein; 6) in healthy women orally administered 20 mg pure S-(-)equol; and 7) in 6-mo-old infants fed soy infant formula and later, at age 3 y, a soy germ isoflavone supplement. Results: The proportion of unconjugated genistein in plasma from adults and infants who consumed different soy foods, pure genistein, or an isoflavone supplement was |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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