Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules inob/obmice

Autor:	Nancy L. Buechler, Charles E. McCall, Vidula Vachharajani, Barbara K. Yoza, Xianfeng Wang
Rok vydání:	2015
Předmět:	medicine.medical_specialty Endocrinology Diabetes and Metabolism Intercellular Adhesion Molecule-1 Medicine (miscellaneous) Inflammation Resveratrol Sepsis chemistry.chemical_compound Cecum Endocrinology Internal medicine medicine Nutrition and Dietetics biology Activator (genetics) Sirtuin 1 Cell adhesion molecule business.industry medicine.disease medicine.anatomical_structure chemistry Immunology biology.protein medicine.symptom business
Zdroj:	Obesity. 23:1209-1217
ISSN:	1930-7381
Popis:	Objective Obesity, a Sirtuin-1 (SIRT-1) deficient state, increases morbidity and resource utilization in critically ill patients. SIRT-1 deficiency increases microvascular inflammation and mortality in early sepsis. Our objective was to study the effect of resveratrol (RSV), a SIRT-1 activator, on microvascular inflammation in obese septic mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d140048f7009f4bd4cc1ce8d99d2583a https://doi.org/10.1002/oby.21086 Zobrazit plný text záznamu Plný text