| Autor: |
Suresh, Suraj, Sasaki, Ryoki, opie, George, Berryman, Carolyn, Biabani, Mana, Semmler, John, Goldsworthy, Mitchell, Rogasch, Nigel |
| Rok vydání: |
2022 |
| DOI: |
10.17605/osf.io/tjf8p |
| Popis: |
Background: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of brain stimulation that induces a change in corticospinal excitability that lasts beyond the stimulation period, known as neural plasticity. Patterned rTMS protocols like paired pulse TMS (PPS) and quadripulse TMS (QPS) utilise bursts of two or four pulses at different ISIs to induce plasticity. While these paradigms have existed for over 15 years, there is currently only 1 review which has systematically assessed the efficacy of the PPS paradigm and none assessing QPS’s capacity to alter corticospinal excitability. Subsequently, it is paramount that a quantitative review is conducted to empirically determine the degree of both PPS and QPS efficacy to induce change in corticospinal excitability. This will be accomplished by conducting a meta-analysis. Objective: To provide a protocol for a systematic review and meta-analysis on the effects of PPS and QPS on corticospinal excitability, as indexed by changes in motor evoked potential (MEP) amplitude. Methods: The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) will be used as a guideline for this protocol. Results: The systematic review will commence after registration of this protocol on Open Science Framework, where it will be locked and date stamped. Conclusions: rTMS paradigms such as PPS and QPS are considered promising protocols for inducing plasticity in the human motor cortex. The proposed systematic review and meta-analysis is being conducted to quantitatively determine the efficacy of these protocols for inducing plasticity and to assess how variability in protocol parameters effect plasticity outcome. Consequently, this review will provide a comprehensive overview of the magnitude of change in corticospinal excitability with PPS and QPS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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