Thiophenesulfonamides as endothelin receptor antagonists

Autor:	Raju Bore Gowda, Fiona Stavros, Chengde Wu, Ming Fai Chan, Adam Kois, Ilya Okun, Erik Verner
Rok vydání:	1996
Předmět:	Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science respiratory system Pharmacology Biochemistry Affinities In vitro binding Drug Discovery cardiovascular system Molecular Medicine Endothelin receptor Molecular Biology IC50 Etb receptor circulatory and respiratory physiology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:2651-2656
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(96)00496-9
Popis:	The synthesis and in vitro binding affinities of a series of thiophenesulfonamides as ETA selective endothelin receptor antagonists is described. The most potent inhibitor displayed an IC50 of 43 nM and 3 μM to ETA and ETB receptors, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d1396ca14706db2068f5944c3ab4a338 https://doi.org/10.1016/s0960-894x(96)00496-9 Zobrazit plný text záznamu Full Text from ScienceDirect