Cochliones A–D, four new tetrahydrochromanone derivatives from endophyticCochliobolussp
| Autor: | Jie Zhang, Junhua Wu, Qi-Zhi Wang, Yu-Fei Zhang, Yong-Chun Song, Hui Ming Ge, Ren-Xiang Tan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
biology Stereochemistry Metabolite Organic Chemistry Pharmaceutical Science General Medicine Cynodon dactylon Pharmacognosy biology.organism_classification Analytical Chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Cell culture Drug Discovery Molecular Medicine Bioassay Two-dimensional nuclear magnetic resonance spectroscopy Cochliobolus Benzoic acid |
| Zdroj: | Journal of Asian Natural Products Research. 12:485-491 |
| ISSN: | 1477-2213 1028-6020 |
| Popis: | Four new tetrahydrochromanone derivatives, cochliones A-D (1-4), along with three known metabolites, 4-hydroxybenzaldehyde (5), 4-hydroxy-3-(3-methylbut-2-enyl) benzoic acid (6), and 2,2-dimethyl-2H-chromene-6-carboxylic acid (7), were characterized from the culture of Cochliobolus sp. IFB-E039, a fungus that resides inside the healthy root of Cynodon dactylon (Gramineae). The structures of 1-4 were accommodated by their spectral data (UV, IR, CD, HR-ESI-MS, (1)H and (13)C NMR, (1)H-(1)H COSY, HMQC, HMBC, and NOESY). The bioassay for the cytotoxic metabolite showed that cochlione C (3) inhibited human breast adenocarcinoma cell line (MCF-7) and human chronic myeloid leukemia cell line (K562) with IC(50) values of 21.99 and 4.59 microg/ml, respectively. |
| Databáze: | OpenAIRE |
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