Comorbidities, concomitant medications and potential drug-drug interactions with interferon-free direct-acting antiviral agents in hepatitis C patients in Taiwan

Autor:	Ching Chu Lo, Ming-Lung Yu, Pin-Nan Cheng, Craig Brooks-Rooney, Yi Hsiang Huang, Cheng Yuan Peng, Chen-Hua Liu, Jyh Jou Chen, Tsai Yuan Hsieh, Wei Wen Su, Chi Yi Chen, Jia-Horng Kao, Chih-Lin Lin, Qian Ma
Rok vydání:	2018
Předmět:	Ledipasvir medicine.medical_specialty Daclatasvir Dasabuvir Hepatology Sofosbuvir business.industry Gastroenterology Hepatitis C medicine.disease Ombitasvir Pibrentasvir 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Concomitant Internal medicine medicine 030211 gastroenterology & hepatology Pharmacology (medical) 030212 general & internal medicine business medicine.drug
Zdroj:	Alimentary Pharmacology & Therapeutics. 48:1290-1300
ISSN:	0269-2813
DOI:	10.1111/apt.15011
Popis:	Background While direct-acting antivirals have been approved for treating hepatitis C, the guidelines highlight the importance of considering potential drug-drug interactions between DAAs and concomitant medications. Aim To assess comorbidity prevalence, concomitant medication use and potential drug-drug interactions between DAAs and concomitant medications for hepatitis C patients in Taiwan. Methods This cross-sectional study enrolled 822 patients from May to August 2016 in Taiwan. Patient demographics, comorbidities and concomitant medications were evaluated by physician surveys. Results A total of 709 (86.3%) patients had ≥1 comorbidity; the most prevalent comorbidity categories were diseases of the digestive system (40.1%), circulatory system (38.7%) and endocrine/nutritional/metabolic diseases (35.2%). Elderly patients had more comorbidities. A total of 622 (75.7%) patients received ≥1 concomitant medication; the average number of concomitant medications was 3.2. The most common concomitant medication classes were cardiovascular (34.4%), gastrointestinal (25.7%) and central nervous system drugs (22.7%). Among patients without cirrhosis or with compensated cirrhosis, contraindications were most prevalent with paritaprevir/ritonavir/ombitasvir plus dasabuvir, daclatasvir/asunaprevir and glecaprevir/pibrentasvir (13.3%, 6.0% and 5.4% respectively), and least prevalent with sofosbuvir, sofosbuvir/daclatasvir, sofosbuvir/ledipasvir and sofosbuvir/velpatasvir (0.8%, 1.3%, 1.4% and 2.1% respectively). Sofosbuvir-based regimens had no contraindications in patients with decompensated cirrhosis. Conclusion Our population represented an elderly demographic, with a high prevalence of comorbidities and widespread use of concomitant medications. The potential drug-drug interactions between these concomitant medications and DAA regimens differed, with the fewest potential interactions with sofosbuvir-based regimens.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d133d426ca8ba80e13c0bd261f2c7d70 https://doi.org/10.1111/apt.15011 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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