Acute tubulointerstitial nephritis, treatment with steroid and impact on renal outcomes
| Autor: | Coralie Bingham, Muhammad N Raza, Muhammad Hadid, Charles E Keen, Andrew H J Salmon |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Incidence (epidemiology) Renal function Retrospective cohort study General Medicine Odds ratio medicine.disease Gastroenterology Endocrinology Nephrology Internal medicine Biopsy medicine Acute tubulointerstitial nephritis business Nephritis Chi-squared distribution |
| Zdroj: | Nephrology. 17:748-753 |
| ISSN: | 1320-5358 |
| DOI: | 10.1111/j.1440-1797.2012.01648.x |
| Popis: | Background: The use and timing of steroids in the management of acute tubulointerstitial nephritis (ATIN) remains debatable. Aims: To determine the incidence and aetiology of ATIN in our unit, and to examine trends in the use of steroids and their impact on renal outcomes. Methods: Patients with a histological diagnosis of ATIN over a 9-year period were identified and divided into steroid-treated (StG) and steroid-naive groups (SnG). Mean change in estimated glomerular filtration rate (eGFR) was determined. Results: Forty-nine patients had ATIN as their main diagnosis, 67% of cases were drug-induced, and proton pump inhibitors (PPI) were the second commonest implicated drug category. Majority (75%) of patients received steroids, and eGFR improved to a significantly greater degree in these steroid-treated patients (3.4-fold improvement vs 2.0-fold in SnG; P 0.45), and no difference in eGFR at the time of last follow-up (StG: 33 ± 3; SnG: 32 ± 7; P > 0.9, unpaired t-test). Conclusion: StG patients had a greater degree of improvement in renal function, but with no correlation between degree of improvement in eGFR and delay in starting steroids, and similar eGFR values at final follow-up. PPI were the second commonest drug category among drug-induced cases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|