Aliphatic polyesters. I. The degradation of poly(ϵ-caprolactone)in vivo

Autor:	D. M. Klimas, A. Schindler, F. I. Chasalow, Y. M. Hibionada, C. G. Pitt
Rok vydání:	1981
Předmět:	Materials science Polymers and Plastics Intrinsic viscosity General Chemistry Cleavage (embryo) Surfaces Coatings and Films Polyester Autocatalysis Hydrolysis Crystallinity Polymer chemistry Materials Chemistry Degradation (geology) Particle size
Zdroj:	Journal of Applied Polymer Science. 26:3779-3787
ISSN:	1097-4628 0021-8995
DOI:	10.1002/app.1981.070261124
Popis:	The degradation of poly(ϵ-caprolactone) in rabbits, rats, and water was studied by measurement of changes in intrinsic viscosity, molecular weight, crystallinity, Young's modulus, and weight. Degradation proceeds by nonenzymatic random hydrolytic cleavage of ester linkages. The process is autocatalytic, and the kinetic relationship Mn/Mno = exp(–kt) is observed until the Mn has decreased to approximately 5000. Significant weight loss is not observed until this point but, once initiated, the rate of weight loss depends markedly on the particle size. Chain scission is associated with an increase in crystallinity, which partly determines the rate of degradation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d12d6f34900ae1bd3ee42a20fb719841 https://doi.org/10.1002/app.1981.070261124 Zobrazit plný text záznamu Plný text