Genomewide association study of reproductive efficiency in female cattle1,2,3,4

Autor:	Warren M Snelling, Timothy P. L. Smith, John B. Cole, Larry A. Kuehn, Tara G. McDaneld, John W. Keele, E. J. Pollak, Milt Thomas
Rok vydání:	2014
Předmět:	Genetics education.field_of_study Reproductive success Population Genome-wide association study General Medicine Biology Beef cattle Breed Genetic marker SNP Animal Science and Zoology education Genotyping Food Science
Zdroj:	Journal of Animal Science. 92:1945-1957
ISSN:	1525-3163 0021-8812
DOI:	10.2527/jas.2012-6807
Popis:	Reproductive efficiency is of economic importance in commercial beef cattle production, as failure to achieve pregnancy reduces the number of calves marketed per cow exposed. Identification of genetic markers with predictive merit for reproductive success would facilitate early selection of sires with daughters having improved reproductive rate without increasing generation intervals. To identify regions of the genome harboring variation affecting reproductive success, we applied a genomewide association study (GWAS) approach based on the >700,000 SNP marker assay, using a procedure based on genotyping multianimal pools of DNA to increase the number of animals that could be genotyped with available resources. Cows from several populations were classified according to reproductive efficiency, and DNA was pooled within population and phenotype prior to genotyping. Populations evaluated included a research population at the U.S. Meat Animal Research Center, 2 large commercial ranch populations, and a number of smaller populations (
Databáze:	OpenAIRE
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