| Popis: |
Cav1.2 calcium channels are the principal proteins involved in electrical, mechanical, and/or signaling functions of the cell.Cav1.2 couples membrane depolarization to the transient increase in intracellular Ca2+concentration that is a trigger for muscle contraction and CREB-dependent transcriptional activation. The CACNA1C gene coding for theCav1.2 pore-formingα1Csubunit is subject to extensive alternative splicing. This review is the first attempt to follow the association between cell proliferation,Cav1.2 expression and splice variation, and atherosclerosis. Based on insights into the association between the atherosclerosis-induced molecular remodeling ofCav1.2, proliferation of vascular smooth muscle cells, and CREB-dependent transcriptional signaling, this review will give a perspective outlook for the use of the CACNA1C exon skipping as a new potential gene therapy approach to atherosclerosis. |
