| Autor: |
Gongcheng Li, Moo Rim Kang, Long-Cheng Li, Jinchun Xing, Tiejun Pan |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
RNA Activation ISBN: 9789811043093 |
| DOI: |
10.1007/978-981-10-4310-9_16 |
| Popis: |
Small activating RNAs (saRNAs) are a class of artificially designed short duplex RNAs targeted at the promoter of a particular gene to upregulate its expression via a mechanism known as RNA activation (RNAa) and hold great promise for treating a wide variety of diseases including those undruggable by conventional therapies. The therapeutic benefits of saRNAs have been demonstrated in a number of preclinical studies carried out in different disease models including cancer. With many tumor suppressor genes (TSGs) downregulated due to either epigenetic mechanisms or haploinsufficiency resulting from deletion/mutation, cancer is an ideal disease space for saRNA therapeutics which can restore the expression of TSGs via epigenetic reprogramming. The p21WAF1/CIP gene is a TSG frequently downregulated in cancer and an saRNA for p21WAF1/CIP known as dsP21-322 has been identified to be a sequence-specific p21WAF1/CIP activator in a number of cancer types. In this chapter, we review preclinical development of medicinal dsP21-322 for cancer, especially prostate cancer and bladder cancer, and highlight its potential for further clinical development. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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