Evaluation of Cystatin C as A Predictor of Coronary Artery Disease in Type 2 Diabetes
| Autor: | M. Amuba Singh, Tilakeswari L, Premchandra Singh Y, Joshita L, Bablu Sukla Das, Sachin Deba Th, Shaini L |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
education.field_of_study biology business.industry Population Type 2 Diabetes Mellitus Type 2 diabetes medicine.disease Surgery Sudden cardiac death Coronary artery disease Cystatin C Internal medicine Diabetes mellitus biology.protein Medicine Endothelial dysfunction business education |
| Zdroj: | IOSR Journal of Dental and Medical Sciences. 11:53-60 |
| ISSN: | 2279-0853 2279-0861 |
| DOI: | 10.9790/0853-1115360 |
| Popis: | Introduction: The association between Coronary Artery Disease (CAD) and diabetes is strong and has led to screening strategies in diabetic patients even before they are symptomatic. Diabetic patients often are unaware of myocardial ischemic pain, and so silent myocardial infarction and ischemia are markedly increased in this population. There is a high chance of developing sudden cardiac death in those with diabetes. Aims and Objects: To estimate the serum total cystatin C (CsTc) value in type 2 diabetes mellitus (DM-2) with CAD and in normal individuals. and to find out the correlation of serum CsTc, Lipid parameters and Glycosylated Hemoglobin (HbA1c) between patients of DM-2 with or without CAD. Materials And Methods: The study was conducted in Department of Biochemistry, RIMS in collaboration with Dept of Medicine, RIMS, Imphal, Manipur and Dept of Anaesthesiology &ICU,RIMS,Imphal for a period of two years. Cases: 60 patients above 18 years of age, fulfilling criteria of diagnosis of Type 2 diabetes mellitus based on WHO definition,which were divided into two subgroups of 30 patients each. Dm-Group: DM-2 (controlled or without complications) and Dm+Cad -Group: DM-2 with confirmed cardiovascular complications. Clinical data ,Lipid parameters , blood Glucose, HBAic were estimated by standard methods. Statistical analysis were done Conclusion: The study have shown a positive and strong evidence of higher mean serum CsTc levels in patients of DM-2 with CAD suggesting that total serum CsTc level is one of the risk factors predisposingCAD. Total serum CsTc levels are found to be higher in male both in patients of DM-2 with and without CAD as well as in controls compared to their respective female counterparts. Thus, a serum CsTc level finds a link an endothelial dysfunction marker and the development of coronary artery disease. |
| Databáze: | OpenAIRE |
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