ChemInform Abstract: Highly Selective Intermolecular Heck Reaction for the Soluble Polymer Supported Synthesis of Glutamic Acid Analogues

Autor:	Jean Martinez, Frédéric Lamaty, Bérengère Sauvagnat, René Lazaro
Rok vydání:	2010
Předmět:	Olefin fiber Chemistry Heck reaction Intermolecular force Organic chemistry Substrate (chemistry) Stereoselectivity Sequence (biology) General Medicine Glutamic acid Alkylation
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200212230
Popis:	Analogues of the neurotransmitter glutamic acid were synthesized by performing a Heck reaction on 4-methylene glutamic acid analogue. This reaction has proved to be highly regio- and stereoselective in the formation of trisubstituted olefin derivatives. A soluble polymer supported substrate yielded similar results and provided an efficient method for the parallel synthesis of novel glutamic acid derivatives. Furthermore a one-pot Pd-catalyzed alkylation/Heck arylation sequence has been developed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d1012cce3b1f5ea72677f141d4af7aec https://doi.org/10.1002/chin.200212230 Zobrazit plný text záznamu Plný text