C-Terminal modification of polytheonamide B uncouples its dual functions in MCF-7 cancer cells

Autor:	Yun-Wei Xue, Kensuke Miura, Hiroaki Itoh, Masayuki Inoue
Rok vydání:	2023
Předmět:	Materials Chemistry Metals and Alloys Ceramics and Composites General Chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials
Zdroj:	Chemical Communications. 59:3914-3917
ISSN:	1364-548X 1359-7345
DOI:	10.1039/d2cc05915k
Popis:	Polytheonamide B is a large natural product that forms an ion channel in the plasma and lysosomal membranes. Herein, we report the uncoupling of the dual functions of polytheonamide B by synthetically incorporating a tertiary amine at the C-terminus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d0fcaf5930b2498a55128e7c63bba169 https://doi.org/10.1039/d2cc05915k Zobrazit plný text záznamu