Antibacterial and biological properties of coconut oil loaded poly(ε-caprolactone)/gelatin electrospun membranes
| Autor: | Parian S Mohamadi, Ahmad Hivechi, Nahid hemmatinegad, Hajir Bahrami, Peiman Brouki Milan |
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| Rok vydání: | 2021 |
| Předmět: |
food.ingredient
Materials science Polymers and Plastics Biocompatibility Materials Science (miscellaneous) Coconut oil technology industry and agriculture 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Electrospun membranes 01 natural sciences Gelatin Industrial and Manufacturing Engineering 0104 chemical sciences chemistry.chemical_compound food chemistry Chemical engineering Biological property Nanofiber Chemical Engineering (miscellaneous) 0210 nano-technology Antibacterial activity Caprolactone |
| Zdroj: | Journal of Industrial Textiles. 51:906S-930S |
| ISSN: | 1530-8057 1528-0837 |
| DOI: | 10.1177/1528083721991595 |
| Popis: | Coconut oil (CO) is a naturally derived bio-oil which exhibits specific characteristics such as biocompatibility and antibacterial activity. In this work, the biological properties of poly(caprolactone)/gelatin (PCL/Gel) nanofibers are improved using CO encapsulation. This bio-oil was added to the PCL/Gel polymer solution with different concentrations (5–40%). Nanofibers were crosslinked using glutaraldehyde vapor. Different types of characterization techniques such as SEM, FTIR, DSC, tensile measurements, water contact angle, and water vapor permeability were used to study the chemical, physical, thermal, and morphological properties of resultant nanofibers. Results showed an average diameter of 300–370 nm for as-spun nanofibers, which increased to 360–470 nm after the crosslinking reaction. The presence of CO was confirmed using FTIR and DSC experiments. Moreover, results indicated that the presence of CO increases the hydrophilicity and water vapor permeability of nanofibers, which are desirable for their final application. Biological tests, such as antibacterial activity, cell viability, and cell morphology tests were performed to evaluate the possible application of the produced nanofibers for wound healing applications. Results indicated that the crosslinked PCL/Gel nanofibers containing 20% CO exhibited the highest cell compatibility and antibacterial activity against gram-positive (S. aureus) and gram-negative ( E. coli) bacteria. |
| Databáze: | OpenAIRE |
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