Arylpiperazine derivatives of diphenylsulfide: Synthesis and evaluation for dual 5-HT1A/SSRI activities

Autor:	Ai-Jun Li, Xue Dan Wu, Xue Qin Zhou, Dong Zhi Liu
Rok vydání:	2008
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Transporter General Chemistry Arylpiperazine derivatives Lead compound Dual (category theory) Biological evaluation
Zdroj:	Chinese Chemical Letters. 19:291-294
ISSN:	1001-8417
Popis:	The design, synthesis and biological evaluation of a novel series of arylpiperazine derivatives of diphenylsulfide with dual 5-HT 1A /SSRI activities are reported. The target compounds exhibit low to moderate 5-HT transporter affinity and moderate to high 5-HT 1A affinity. Compound 13a shows moderate dual activities and is a promising lead compound for further structure–activity relationships studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d0f31db993703323b59c784c524bfc64 https://doi.org/10.1016/j.cclet.2008.01.015 Zobrazit plný text záznamu Full Text from ScienceDirect