Hypouricemic and arthritis relapse-reducing effects of compound tufuling oral-liquid in intercritical and chronic gout
| Autor: | Xiaoqing Jing, Yasong Li, Zhijun Xie, Xiaopo Tang, Chengping Wen, Jing Sun, Yongmei Han, Huaxiang Wu, Yongshen Fan, Xiuyang Li, Xiangfu Gao |
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| Rok vydání: | 2017 |
| Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty business.industry Arthritis General Medicine medicine.disease Placebo Gastroenterology Confidence interval Gout law.invention Surgery Clinical trial 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Randomized controlled trial law Internal medicine medicine Uric acid 030212 general & internal medicine Adverse effect business |
| Zdroj: | Medicine. 96:e6315 |
| ISSN: | 0025-7974 |
| Popis: | TRIAL DESIGN In the double-blind, randomized, controlled trial, we aimed to evaluate the effects of compound tufuling oral liquid (CoTOL) on serum uric acid (sUA) levels and recurrence of acute gouty arthritis in intercritical and chronic gout treatment. METHODS A total of 210 patients with gout were screened from 8 hospitals to observe the sUA and acute gouty arthritis recurrence rate-reducing effects of CoTOL in intercritical and chronic gout during a 12-week treatment. We treated 139 and 71 patients with CoTOL and the placebo, respectively, and evaluated their sUA levels, acute gouty arthritis recurrence rate, and adverse events at week 0, 6, and 12. RESULTS Twenty-five and 12 patients in the treatment and control groups, respectively, had interrupted treatments, whereas 114 and 59 cases, respectively, completed their treatments. At the end of the 12-week treatment, the average decrease in sUA was 74.26 (95% confidence interval [CI]: 56.74-91.77 μmol/L) and 28.81 μmol/L (95% CI: 4.91-52.71 μmol/L) in the treatment and control groups, respectively (P = 0.004). The average decrease rate of sUA was 12.76% (95% CI: 9.82%-15.70%) and 4.57% (95% CI: 0.42%-8.71%) in the treatment and control groups, respectively (P = 0.004), and the gouty arthritis recurrence rate of the treatment group was lower than that of the control group (from week 6 to 12, 21.93% and 50.88% in the treatment and control group, respectively, P |
| Databáze: | OpenAIRE |
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