Sepicanin A—A new geranyl flavanone from Artocarpus sepicanus with activity against methicillin-resistant Staphylococcus aureus (MRSA)
| Autor: | Mohamed M. Radwan, Samir A. Ross, Susan P. Manly, Melissa R. Jacob, Raquel Rodríguez-Guzmán |
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| Rok vydání: | 2009 |
| Předmět: |
Artocarpus sepicanus
Stereochemistry Plant Science Antimicrobial medicine.disease_cause Biochemistry Methicillin-resistant Staphylococcus aureus Microbiology chemistry.chemical_compound chemistry Glucoside Staphylococcus aureus medicine Antibacterial activity Agronomy and Crop Science Flavanone IC50 Biotechnology |
| Zdroj: | Phytochemistry Letters. 2:141-143 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2009.04.002 |
| Popis: | Bioassay-guided fractionation of the EtOH extract of Artocarpus sepicanus Diels leaves has led to the isolation of a new geranyl flavanone (1), along with the known compounds, afzelechin-3-O-α- l -rhamnopyranoside and β-sitosterol glucoside. The structure of the new compound was established by UV, IR, HRESIMS, 1D and 2D NMR experiments. Antimicrobial testing of the three compounds indicated that 1 displayed a significant selective antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with IC50 and MIC values of 1.4 and 2.9 μM, respectively. |
| Databáze: | OpenAIRE |
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