1,3-Diphenylpropane-1,3-diamines XI. Conversion of a 3-hydroxy-1,3-diphenylpropan-1-one to 1,3-diphenylpropane-1,3-diamines

Autor:	Wolfgang Wiegrebe, A. Kaiser, P. Bielmeier
Rok vydání:	1997
Předmět:	chemistry.chemical_compound chemistry Mesylate Thiophenol General Chemistry Azide Cleavage (embryo) Medicinal chemistry
Zdroj:	Monatshefte f�r Chemie Chemical Monthly. 128:1247-1254
ISSN:	1434-4475 0026-9247
Popis:	Highly diastereoselective BH3/THF syn-reduction of the 3-hydroxy-1,3-diphenylpropan-1-one/BBr3 complex3/BBr3 (cf.Sarko) afforded themeso-diol4, whereas racemate5 was obtained by BH3/THF reduction without complexation. Mesylation, exchange of mesylate by azide, and reduction with SnCl2/thiophenol led to the diamines10 and11 which were also produced by reductive N-N cleavage of the 4,5-dihydropyrazole13.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d0e6ce3ce980dfcc25e5540da631a308 https://doi.org/10.1007/bf00807256 Zobrazit plný text záznamu Full text from SpringerLink