Novel derivatives at the C21 position of the FK-506 macrocycle
| Autor: | Francis J. Dumont, Judith M. Pisano, Mary Jo Staruch, Helen M. Organ, Peter J. Sinclair, Matthew J. Wyvratt, Mark A. Holmes |
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| Rok vydání: | 1993 |
| Předmět: | |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:657-662 |
| ISSN: | 0960-894X |
| Popis: | A number of C21 derivatives of FK-506 were prepared and their immunosuppressant properties evaluated in a T-cell proliferation assay. Some of these compounds are surprisingly potent antagonists of FK-506-mediated immunosuppression. |
| Databáze: | OpenAIRE |
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